The RaTg13 S does not bind to any ACE2 with affinity and entry capacity that is viable for Sarbecoviruses.

The RaTg13 S does not bind to any ACE2 with affinity and entry capacity that is viable for Sarbecoviruses. This includes both human ACE2 and ACE2 Ra4331, which had even lower binding efficiency and infection efficiency than human ACE2.

(Click on image for large view)

The SARS-CoV-2 S is uniquely adapted to human ACE2.

Reference:

https://www.nature.com/articles/s41421-020-00210-9

https://www.nature.com/articles/s41421-020-00210-9/figures/2

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